2007 Technical Progress

Peer-Reviewed Publications

• Iron Oxide Nanoparticles as a Drug Delivery Vehicle for MRI Monitored Magnetic Targeting of Brain Tumors,  Chertok B, Moffat BA, David AE, Yu F, Bergemann C, Ross BD, Yang VC, Biomaterials. 2008 Feb;29(4):487-96. Epub 2007 Oct 26

• Reaching for High-Hanging Fruit in Drug Discovery at Protein-Protein Interfaces, Wells JA, McClendon CL, Nature. 2007 Dec 13;  450(7172):1001-9

• Iterative Projection Reconstruction of Time-Resolved Images Using Highly-Constrained Back-Projection (HYPR), O'Halloran RL, Wen Z, Holmes JH, Fain SB, 2007 Dec 3;59(1):132-139 [Epub ahead of print]

• TEM Transmission Line Coil With Double Nuclear Capability, Erickson MG, Kurpad KN, Holmes JH, Fain SB, Magn Reson Med. 2007 Oct;58(4):800-7

• Imaging of Lung Ventilation and Respiratory Dynamics in a Single Ventilation Cycle Using Hyperpolarized He-3 MRI, Holmes JH, Korosec FR, Du J, O'halloran RL, Sorkness RL, Grist TM, Kuhlman JE, Fain SB, J Magn Reson Imaging 2007 Sep; 26(3):630-6 

• An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury, Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Bromme D, Silverman GA, Cell. 2007 Sep 21;130(6):1108-19
  
  
• Severe Facial Clefting in Insig-Deficient Mouse Embryos Caused by Sterol Accumulation and Reversed by Lovastatin, Engelking LJ, Evers BM, Richardson JA, Goldstein JL, Brown MS, Liang G, J Clin Invest. 2006 Sep; 11; 6(9):2356-65
  
  
• Magnetic Microposts as an Approach to Apply Forces to Living Cells, Sniadecki NJ, Anguelouch A, Yang MT, Lamb CM, Liu Z, Kirschner SB, Liu Y, Reich DH, Chen CS, Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14553-14558

• In Vitro Assessment of a Novel Polyrotaxane-Based Drug Delivery System Integrated With a Cell-Penetrating Peptide, Moon C, Kwon YM, Lee WK, Park YJ, Yang VC, J Control Release. 2007 Dec 4;124(1-2):43-50. Epub 2007 Sep 5

• Continuous Time-Domain Analysis of Cerebrovascular Autoregulation Using Near- Infrared Spectroscopy, Brady KM, Lee JK, Kibler KK, Smielewski P, Czosnyka M, Easley RB, Koehler RC, Shaffner DH, 2007 Oct;38(10):2818-25. Epub 2007 Aug 30

• Serpin B11 is a New Noninhibitory Intracellular Serpin: Common Single Nucleotide Polymorphisms in the Scaffold Impair Conformational Change, Askew DJ, Cataltepe S, Kumar V, Edwards C, Pace SM, Howarth RN, Pak SC, Askew YS, Bromme D, Luke CJ, Whisstock JC, Silverman GA, J Biol Chem. 2007 Aug 24, 282(34): 24948-60
  
  
• Cortico-Striatal Synaptic Defects and OCD-Like Behaviours in Sapap3-Mutant Mice, Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD, Feliciano C, Chen M, Adams JP, Luo J, Dudek SM, Weinberg RJ, Calakos N, Wetsel WC, Feng G, Nature 2007 Aug 23, 448(7156):894-900
  
  
• Dimorphism and Virulence in Fungi, Klein BS, Tebbets B, Curr Opin Microbiol. 2007 Aug;           10(4):314-9. Epub 2007 Aug 23

• Detection and Measurement of Two-Component systems that Control Dimorphism and Virulence in Fungi, Nemecek JC, Wuthrich M, Klein BS, Methods Enzymol. 2007, 422:465-87
  
  
• Computational Approach to Site-Directed Ligand Discovery, Toth G, Mukhyala K, Wells JA, Proteins. 2007 Aug 1, 68(2):551-60 
  
  
• Development and Application of a Green Fluorescent Protein Sentinel System for Identification of RNA Interference in Blastomyces Dermatitidis Illuminates the Role of Septin in Morphogenesis and Sporulation, Krajaejun T, Gauthier GM, Rappleye CA, Sullivan TD, Klein BS, Eukaryot Cell. 2007 Aug; 6(8): 1299-309

• Effects of Uniaxial Cyclic Strain on Adipose-Derived Stem Cell Morphology, Proliferation, and Differentiation, Lee WC, Maul TM, Vorp DA, Rubin JP, Marra KG, Biomech Model Mechanobiol. 2007 Jul; 6(4):265-73

• Correlation Between Histology and PAX/FKHR Fusion Status in Alveolar Rhabdomyosarcoma: a Report from the Children's Oncology Group,    Parham DM, Qualman SJ, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer WH; Soft Tissue Sarcoma Committee of the Children's Oncology Group, Am J Surg Pathol. 2007 Jun, 31(6):895-901

• Microfabricated Silicone Elastomeric Post Arrays for Measuring Traction Forces of Adherent Cells, Sniadecki NJ, Chen CS, Methods Cell Biol. 2007; 83:313-28

• Prestin-Based Outer Hair Cell Electromotility in Knockin Mice Does Not Appear to Adjust the Operating Point of a Cilia-Based Amplifier, Gao J, Wang X, Wu X, Aguinaga S, Huynh K, Jia S, Matsuda K, Patel M, Zheng J, Cheatham M, He DZ, Dallos P, Zuo J, Proc Natl Acad Sci U S A. 2007 Jul 24, 104(30):12542-7
  
  
• Global Gene Expression Profiling of PAX-FKHR Fusion-Positive Alveolar and PAX-FKHR Fusion-Negative Embryonal  Rhabdomyosarcomas, Laé M, Ahn EH, Mercado GE, Chuai S, Edgar M, Pawel BR, Olshen A, Barr FG, Ladanyi M, JJ Pathol. 2007 Jun, 212(2):143-51
  
  
• Protein Interfacial Pocket Engineering Via Coupled Computational Filtering and Biological Focusing Criterion, Reza F, Zuo P, Tian J, Ann Biomed Eng. 2007 Jun, 35(6):1026-36
  
  
• Glioma Selectivity of Magnetically Targeted Nanoparticles: a Role of Abnormal Tumor Hydrodynamics, Chertok B, David AE, Huang Y, Yang VC, 2007 Oct 8;122(3):315-23. Epub 2007 Jun 2

• Mechanical Stimulation Induces Morphological and Phenotypic Changes in Bone Marrow-Derived Progenitor Cells Within a Three-Dimensional Fibrin Matrix, Nieponice A, Maul TM, Cumer JM, Soletti L, Vorp DA, J Biomed Mater Res A. 2007 Jun 1; 81(3):523-30

• 2007 Press Releases, News Stories and Awards